Annals of internal medicine
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Comment Randomized Controlled Trial
In T2DM with CKD, semaglutide reduced major kidney disease events at 3 y.
Perkovic V, Tuttle KR, Rossing P, et al; FLOW Trial Committees and Investigators. Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes. N Engl J Med. 2024;391:109-121. 38785209.
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Knee osteoarthritis (OA) typically presents with joint pain that is exacerbated by use and alleviated with rest. There is relatively brief, self-limited morning stiffness and absence of constitutional symptoms. ⋯ As the severity of disease increases, the magnitude of pain and functional impairment intensifies. Surgical intervention should be pursued to relieve pain and restore functionality only when nonpharmacologic approaches and pharmacologic agents fail to control pain.
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Multicenter Study
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.
There are currently no validated clinical biomarkers of postacute sequelae of SARS-CoV-2 infection (PASC). ⋯ National Institutes of Health.
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Comparative Study Observational Study
Effect of Starting Dialysis Versus Continuing Medical Management on Survival and Home Time in Older Adults With Kidney Failure : A Target Trial Emulation Study.
For older adults with kidney failure who are not referred for transplant, medical management is an alternative to dialysis. ⋯ U.S. Department of Veterans Affairs and National Institutes of Health.
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Racial disparities in firearm injury death in the United States are well established. Less is known about the magnitude of nonfatal and total firearm injury. ⋯ None.