Annals of surgery
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To determine the efficacy of splenectomy for treating thrombocytopenia associated with systemic lupus erythematosus (SLE). ⋯ Splenectomy should be considered safe and efficacious for thrombocytopenia associated with SLE.
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Comment Letter
Are actual standard fluid regimens in major surgery safe?
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Randomized Controlled Trial Comparative Study Clinical Trial
The educational impact of bench model fidelity on the acquisition of technical skill: the use of clinically relevant outcome measures.
To evaluate the impact of bench model fidelity on the acquisition of technical skill using clinically relevant outcome measures. ⋯ Surgical skills training on low-fidelity bench models appears to be as effective as high-fidelity model training for the acquisition of technical skill among novice surgeons.
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Comparative Study
Anterior resection for rectal cancer with mesorectal excision: a prospective evaluation of 622 patients.
This study aims to review the operative results and oncological outcomes of anterior resection for rectal and rectosigmoid cancer. Comparison was made between patients with total mesorectal excision (TME) for mid and distal cancer and partial mesorectal excision (PME) for proximal cancer, when a 4- to 5-cm mesorectal margin could be achieved. Risk factors for local recurrence and survival were also analyzed. ⋯ Anterior resection with mesorectal excision is a safe option and can be performed in the majority of patients with rectal cancer. The local recurrence rate was 9.7% and the cancer-specific survival was 74.5%. When the tumor requires a TME, this procedure is more complex and has a higher leakage rate than in those higher tumors where PME provides adequate mesorectal clearance. By performing TME in patients with mid and distal rectal cancer, the local control and survival of these patients are similar to those of patients with proximal cancers where adequate clearance can be achieved by PME.
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Comparative Study
Adrenomedullin and adrenomedullin binding protein-1 attenuate vascular endothelial cell apoptosis in sepsis.
To determine whether vascular endothelial cell apoptosis occurs in the late stage of sepsis and, if so, whether administration of a potent vasodilatory peptide adrenomedullin and its newly reported specific binding protein (AM/AMBP-1) prevents sepsis-induced endothelial cell apoptosis. ⋯ The above results suggest that vascular endothelial cell apoptosis occurs in late sepsis and the anti-apoptotic effects of AM/AMBP-1 appear to be in part responsible for their beneficial effects observed under such conditions.