Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Dec 2022
Case ReportsSurgery for an Isolated Adrenal Metastasis of Gastric Cancer.
Adrenal metastasis is considered a rare hematogenous metastasis that develops after gastric cancer surgery. The chances of curative surgery are very low. It is usually unresectable. ⋯ The option of surgical treatment is recommended for isolated metachronous adrenal metastases. Curative surgical resection may positively impact the prognosis of patients in selected cases. Key Words: Gastric cancer, Adrenal metastasis, Surgical resection.
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J Coll Physicians Surg Pak · Dec 2022
Case ReportsStem Cell Transplantation in Glanzmann's Thrombasthenia: A Report of Two Adult Patients.
Glanzmann's thrombasthenia (GT) is an autosomal recessive bleeding disorder characterised by mucocutaneous bleeding. At molecular level, defect in platelet receptor glycoprotein (GP) IIb/IIIa leads to defective platelet aggregation. Anti-fibrinolytic agents, platelet transfusions, and factor rVIIa are used for prophylaxis before invasive procedures and treatment of bleeding events. ⋯ Both showed marked improvement in quality of life. To conclude, stem cell transplant is a viable treatment option for severe, difficult-to-control cases of GT. Key Words: Platelet disorders, Hematopoietic stem cell transplantation, Thrombasthenia.
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J Coll Physicians Surg Pak · Dec 2022
Case ReportsPeripheral Odontogenic Keratocyst of Buccal Mucosa.
The odontogenic keratocyst is a developmental cystic lesion of jaw bones. There is an on-going debate about the pathogenesis of this entity. Odontogenic keratocysts are usually seen intraosseously in jaws with a predilection in the mandibular molar ramus regions. ⋯ The diagnosis was made on biopsy of the lesion. The lesion was excised completely. Key Words: Buccal mucosa, Pathology, Keratocyst, Odontogenic.
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J Coll Physicians Surg Pak · Dec 2022
Case ReportsNecrotizing Fasciitis Associated with Hailey-Hailey Disease: A Rare Case.
Necrotizing fasciitis (NF) is a rare and life-threatening infection of soft tissue characterised by rapid and extensive destruction of the skin, subcutaneous fat, and fascia. Early diagnosis of NF is challenging, and it can be very difficult to distinguish NF from other infectious diseases of skin and subcutaneous tissue. ⋯ Clinicians should be alert to signs and symptoms of NF in HHD and other skin diseases with damaged skin barrier function such as pemphigus, pemphigoid, and all kinds of ulcers, especially in diabetic and immunosuppressed patients. Key Words: Necrotizing fasciitis, Genodermatosis, Hailey-Hailey disease.
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Myasthenia gravis (MG) affects the ocular, bulbar, and proximal limb muscles. The involvement of distal limb muscles is uncommon. MG-related weakness that severely affects the finger flexors and spares finger extensors and intrinsic hand muscles have never been reported. ⋯ The patient had a good recovery with immunotherapy. We conclude that clinicians should be aware that marked weakness of the finger flexors can occur as a result of an MG relapse and may require early aggressive therapy. Key Words: Electromyography, Finger flexors, Muscle, Biopsy, Myasthenia gravis.