Health technology assessment : HTA
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Health Technol Assess · Oct 2018
Randomized Controlled Trial Multicenter StudyAdjunctive rifampicin to reduce early mortality from Staphylococcus aureus bacteraemia: the ARREST RCT.
Staphylococcus aureus bacteraemia is a common and frequently fatal infection. Adjunctive rifampicin may enhance early S. aureus killing, sterilise infected foci and blood faster, and thereby reduce the risk of dissemination, metastatic infection and death. ⋯ Given the substantial mortality, other antibiotic combinations or improved source management should be investigated.
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Health Technol Assess · Oct 2018
Randomized Controlled Trial Multicenter StudyAdding emollient bath additives to standard eczema management for children with eczema: the BATHE RCT.
Childhood eczema is very common. Treatment often includes emollient bath additives, despite there being little evidence of their effectiveness. ⋯ Further research is required on optimal regimens of leave-on emollients and the use of emollients as soap substitutes.
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Health Technol Assess · Oct 2018
Two interferon gamma release assays for predicting active tuberculosis: the UK PREDICT TB prognostic test study.
Despite a recent decline in the annual incidence of tuberculosis (TB) in the UK, rates remain higher than in most Western European countries. The detection and treatment of latent TB infection (LTBI) is an essential component of the UK TB control programme. ⋯ The National Institute for Health Research Health Technology Assessment programme.