European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
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Eur. J. Paediatr. Neurol. · Jan 2014
Multicenter StudyEfficacy and safety of lacosamide in infants and young children with refractory focal epilepsy.
Lacosamide is effective and well-tolerated antiepileptic drug (AED) in both children and adults. ⋯ We conclude that lacosamide is an effective and a well-tolerated antiepileptic drug in an etiologically wide range of focal seizures. Therefore, lacosamide might represent a possible therapeutic option in infants and young children affected by uncontrolled focal epilepsy.
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Eur. J. Paediatr. Neurol. · Jan 2014
Continuation rates of levetiracetam in children from the EULEVp cohort study.
Since indication extension to children data regarding the effectiveness of levetiracetam in paediatric patients remains limited. ⋯ In real-life clinical practice important treatment retention and non-negligible reduction of seizure frequency may be expected.
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Eur. J. Paediatr. Neurol. · Jan 2014
ReviewComparing contents of outcome measures in cerebral palsy using the International Classification of Functioning (ICF-CY): a systematic review.
The International Classification of Functioning children and youth version (ICF-CY) provides a universal framework for defining and classifying functioning and disability in children worldwide. To facilitate the application of the ICF in practice, ICF based-tools like the "ICF Core Sets" are being developed. In the context of the development of the ICF-CY Core Sets for children with Cerebral Palsy (CP), the aims of this study were as follows: to identify and compare the content of outcome measures used in studies of children with CP using the ICF-CY coding system; and to describe the most frequently addressed areas of functioning in those studies. ⋯ The outcome measures contained 2193 concepts that were linked to the ICF-CY and covered 161 independent ICF-CY categories. Out of the 161 categories, 53 (33.5%) were related to body functions, 75 (46%) were related to activities/participation, 26 (16.1%) were related to environmental factors, and 7 (4.3%) were related to body structures. This systematic review provides information about content of measures that may guide researchers and clinicians in their selection of an outcome measure for use in a study and/or clinical practice with children with CP.
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Eur. J. Paediatr. Neurol. · Jan 2014
The effect of continuous intrathecal baclofen on sitting in children with severe cerebral palsy.
To investigate the effect of intrathecal baclofen (ITB) on sitting in children with cerebral palsy with severe spasticity; and identify potential sub-groups of patients at particular risk of deterioration. ⋯ Sitting does not improve or deteriorate in children following treatment with ITB, independent of age or severity of motor impairment.
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Eur. J. Paediatr. Neurol. · Jan 2014
Alternating hemiplegia of childhood in Denmark: clinical manifestations and ATP1A3 mutation status.
Alternating hemiplegia of childhood (AHC) is a rare neurodevelopmental disorder characterized by early-onset recurrent distinctive hemiplegic episodes commonly accompanied by other paroxysmal features and developmental impairment. De novo mutations in ATP1A3 were recently identified as a genetic cause of AHC. To describe the entire Danish cohort of paediatric AHC patients we approached neuropaediatricians nationwide. ⋯ The patients harboured a wide range of psychomotor difficulties. Patients with no mutation detected tended to be less severely affected. Prevalence was approximately 1 per 100,000 children.