European journal of pain : EJP
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Randomized Controlled Trial
Evaluation of the effects of a metabotropic glutamate receptor 5-antagonist on electrically induced pain and central sensitization in healthy human volunteers.
This study aimed to investigate the effect of a single dose of the mGluR5-antagonist AZD9272 on electrically induced pain, central sensitization and axon reflex flare. ⋯ Single doses of the centrally acting mGluR5-antagonist AZD9272 did not reduce C-fibre evoked pain, central sensitization or flare reaction.
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Randomized Controlled Trial
Betamethasone in hernia surgery: A randomized controlled trial.
Post-operative pain and nausea may be a problem in day-case surgery. This study aims to investigate the effect of betamethasone on pain and nausea in inguinal hernia surgery. ⋯ A 12 mg betamethasone reduced pain during the first 24 h and at 1 month after inguinal hernia surgery. If combined with diclofenac, however, this dose may increase the risk for bleeding complications.
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Multicenter Study
Psychiatric co-morbidities in patients with chronic peripheral neuropathic pain: A multicentre cohort study.
Psychiatric co-morbidities are common in patients with chronic pain, but no data are available about their prevalence in patients with neuropathic pain. ⋯ Lifetime and current anxiety and mood disorders are highly prevalent in patients with peripheral neuropathic pain, and are associated with high levels of catastrophizing. Early management of catastrophizing may contribute to reducing the risk of psychiatric co-morbidities in these patients.
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Randomized Controlled Trial
Effectiveness of an 8-week exercise programme on pain and specificity of neck muscle activity in patients with chronic neck pain: A randomized controlled study.
Although exercise can be effective for relief of neck pain, little is known about the effect of exercise on the neural control of neck muscles. ⋯ An exercise programme that aims to enhance motor control of the cervical spine improves the specificity of neck muscle activity and reduces pain and disability in patients with neck pain.
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In the scientific approach to central processing of pain, the habituation phenomenon has been frequently described. Recent studies mentioned electrophysiological habituation during the recording of laser-evoked potentials (LEP). In this study we intended to test whether habituation can be reproducibly induced by repetitive painful laser stimuli and simultaneously measured with LEP. Inspired by findings from previous imaging studies that showed bilateral activation of the operculo-insular cortices, we hypothesized that repetitive painful laser stimuli applied to one hand lead to bihemispheral LEP amplitude habituation. ⋯ Habituation (in the electrophysiological sense) is a physiological phenomenon that indicates normal central processing of pain in healthy controls. We showed bihemispheral N2P2 amplitude habituation after repetitive painful stimulation of the right hand. Our findings propose a bihemishperal contribution to central pain processing and pain modulation when electrophysiological habituation occurs.