La Clinica terapeutica
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La Clinica terapeutica · Mar 1998
Clinical Trial[Phase II study of docetaxel in patients with advanced stage soft tissue sarcoma].
To evaluate the activity and toxicity of docetaxel (TXT) as second line therapy in advanced soft-tissue sarcoma. ⋯ The results of this study do not suggest the use of TXT at this dosage and schedule in advanced soft tissue sarcoma.
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La Clinica terapeutica · Jan 1998
Clinical Trial Controlled Clinical TrialPlatinum compounds as radiosensitizers in strontium-89 metabolic radiotherapy.
Strontium-89 is currently used for the treatment of painful bone metastases. This study reports on two preliminary experiences with low-dose platinum compounds, carboplatin and cisplatin, as radiosensitizers in 89Sr therapy. ⋯ Low-dose platinum compounds seem to enhance the effects of 89Sr radioisotope therapy on pain from bone metastases without relevant hematological toxicity.
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La Clinica terapeutica · Dec 1997
Comparative Study[Use of mivacurium in orthopedic surgery: comparison of 2 different-dose inductions].
The aim of our study was to evaluate the efficiency and safety of mivacurium, comparing two dose-induction in patients undergone a minor orthopaedic surgery. 30 patients were divided into two groups and mivacurium were administered at the dose of 0.15 mg Kg-1 and 0.20 mg Kg-1 respectively. The results confirmed its efficiency in short surgery. Mioresolution was excellent only in the second group (0.20 mg Kg-1) despite an histamine-related blood pressure reduction.
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La Clinica terapeutica · Dec 1997
Randomized Controlled Trial Comparative Study Clinical Trial[Peridural analgesic therapy in orthopedic surgery: comparison of ropivacaine and bupivacaine].
The aim of our study was to compare the efficiency of ropivacaine and bupivacaine, in epidural administration, in postoperative analgesia. 20 patients, undergone knee surgery, in epidural anaesthesia (bupivacaine 0.5%-2 mg/Kg-1 administered in level L3L4), was divided into 2 groups (10 each one) and the local anaesthetics in study was administered by epidural catheter with an elastomeric pump: A (ropivacaine 0.15%) and B (bupivacaine 0.15%). The results demonstrate that ropivacaine is better than bupivacaine to keep a check on analgesia in postoperative pain.