Clinical pharmacology and therapeutics
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Clin. Pharmacol. Ther. · Oct 2001
Comparative Study Clinical TrialIbuprofen pharmacokinetics in preterm infants with patent ductus arteriosus.
Our objective was to study the pharmacokinetics of ibuprofen in premature infants with patent ductus arteriosus on day 3 and day 5 after birth. ⋯ Ibuprofen pharmacokinetics showed a large interindividual variation in premature infants during treatment for patent ductus arteriosus, and significant changes may occur between day 3 and day 5 after birth in those infants with a closing ductus. These findings may have implications for the treatment schedule with ibuprofen in patients with patent ductus arteriosus.