Drugs
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Complicated urinary tract infections are infections in the setting of structural or functional abnormalities of the genitourinary tract. They encompass a wide variety of clinical syndromes and anticipated outcomes. The infecting micro-organisms isolated are more varied and demonstrate a higher prevalence of antimicrobial resistance in complicated compared to uncomplicated urinary tract infections. ⋯ Antimicrobial agents are similar to those used to treat uncomplicated urinary tract infection. Certain agents, such as nitrofurantoin, should be avoided for individuals with renal failure. No specific agent or class of agents has consistently demonstrated greater therapeutic efficacy where the infecting organism is susceptible to the given agent.