Fertility and sterility
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Fertility and sterility · Feb 2019
Comparative StudyPrediction of implantation after blastocyst transfer in in vitro fertilization: a machine-learning perspective.
To develop a random forest model (RFM) to predict implantation potential of a transferred embryo and compare it with a multivariate logistic regression model (MvLRM), based on data from a large cohort including in vitro fertilization (IVF) patients treated with the use of single-embryo transfer (SET) of blastocyst-stage embryos. ⋯ The performance to predict ongoing implantation will significantly improve with the use of an RFM approach compared with MvLRM.
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Fertility and sterility · Feb 2019
Comparative StudyOne hundred mosaic embryos transferred prospectively in a single clinic: exploring when and why they result in healthy pregnancies.
To investigate the parameters of mosaicism and the biological mechanisms leading to healthy pregnancies from mosaic embryo transfers. ⋯ After euploid embryos, mosaic embryos can be considered for transfer, prioritizing those of the single segmental mosaic type. If a patient has mosaic embryos available that were generated at different ages, preference should be given to those made at younger ages. Intrablastocyst karyotype discordance and differential cell proliferation and death might be reasons that embryos classified as mosaic can result in healthy pregnancies and babies.
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Fertility and sterility · Feb 2019
Effect of class III and class IV obesity on oocyte retrieval complications and outcomes.
To assess the effect of class III (body mass index [BMI] 40-49.9 kg/m2) and class IV obesity (BMI ≥ 50 kg/m2) on oocyte retrieval complications and outcomes. ⋯ Serious intraoperative and postoperative complications were uncommon across all BMI groups, though minor complications were more common with class III and class IV obesity. These patients were also more likely to require higher doses of propofol and fentanyl, have longer oocyte retrievals, and require a transabdominal retrieval. Overall, oocyte retrieval can be safely performed as an outpatient procedure in women with class III and class IV obesity.