Fertility and sterility
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Fertility and sterility · Apr 2020
Reproductive and oncologic outcomes after fertility-sparing surgery for early stage cervical cancer: a systematic review.
This review sought to evaluate the current literature on reproductive and oncologic outcomes after fertility-sparing surgery for early stage cervical cancer (stage IA1-IB1) including cold-knife conization/simple trachelectomy, vaginal radical trachelectomy, abdominal radical trachelectomy, and laparoscopic radical trachelectomy with or without robotic assistance. A systematic review using the preferred reporting items for systematic reviews and meta-analysis (PRISMA) checklist to evaluate the current literature on fertility-sparing surgery for early stage cervical cancer and its subsequent clinical pregnancy rate, reproductive outcomes, and cancer recurrence was performed. Sixty-five studies were included encompassing 3,044 patients who underwent fertility-sparing surgery, including 1,047 pregnancies with reported reproductive outcomes. ⋯ Fertility-sparing surgery is a reasonable alternative to traditional radical hysterectomy for early-stage cervical cancer in women desiring fertility preservation. Vaginal radical trachelectomy had the highest clinical pregnancy rate, and minimally invasive approaches to fertility-sparing surgery had equivalent oncologic outcomes compared with an abdominal approach. The results of our study allow for appropriate patient counseling preoperatively and highlight the importance of a multidisciplinary approach to achieve the best outcomes for each patient.
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Fertility and sterility · Apr 2020
Case ReportsUnicornuate uterus with noncommunicating functional horn: diagnostic workup and laparoscopic horn amputation.
To describe the diagnosis and the management of hematometra in a patient with unicornuate uterus with noncommunicating functional horn (hemi uterus and rudimentary uterine hemicavity). ⋯ Laparoscopic amputation of a functional rudimentary horn is considered the basic and traditional surgical option for women with hemiuterus. A detailed diagnostic evaluation should be performed to avoid misdiagnoses of other anomalies with blind hemicavity, which may be treated by hysteroscopy. Laparoscopic surgery with minimally invasive approach could be an essential tool to treat these cases, achieving optimal results with low postsurgical pain and a short hospital stay.
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Fertility and sterility · Dec 2019
Comparative StudyFertility treatments and offspring pediatric infectious morbidities: results of a population-based cohort with a median follow-up of 10 years.
To study the association between mode of conception and offspring infectious morbidity risk. ⋯ Higher risk for infectious morbidity was found among offspring conceived after fertility treatments compared with spontaneously conceived offspring.
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Fertility and sterility · Nov 2019
Randomized Controlled Trial Multicenter StudyRelugolix, a novel oral gonadotropin-releasing hormone antagonist, in the treatment of pain symptoms associated with uterine fibroids: a randomized, placebo-controlled, phase 3 study in Japanese women.
To investigate the efficacy and safety of the oral gonadotropin-releasing hormone receptor antagonist, relugolix, in patients experiencing uterine fibroid-associated pain. ⋯ JapicCTI-163127.
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Fertility and sterility · Sep 2019
Randomized Controlled Trial Multicenter StudyImpact of elagolix on work loss due to endometriosis-associated pain: estimates based on the results of two phase III clinical trials.
To estimate the impact of elagolix on work loss due to endometriosis-associated pain. ⋯ NCT01620528 (EM-I) and NCT01931670 (EM-II).