Fertility and sterility
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Peer-reviewed biomedical journals are expected to publish accurate and important information. In the process, numerous ethical issues may arise from within both the editorial and research communities. This paper will focus on four general ethical issues-authorship, peer review, duplicate or repetitive publication, and conflict of interest. ⋯ Duplicate or repetitive publication, in which the same information is reported two or more times, can damage a journal's reputation for publishing new and important information and can waste its resources. Conflicts of interest, in which financial and personal considerations may affect the investigator's personal judgment, can seriously damage the integrity of the author and of the journal. Increased awareness of these ethical issues should stimulate everyone to take an active role in promulgating and enforcing the highest ethical standards in biomedical publications.
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Fertility and sterility · Apr 2002
Adrenal progestogen and androgen production in 21-hydroxylase-deficient nonclassic adrenal hyperplasia is partially independent of adrenocorticotropic hormone stimulation.
To test the hypothesis that adrenal steroidogenesis in nonclassic adrenal hyperplasia (NCAH) patients is, at least in part, independent of adrenocorticotropic hormone (ACTH) control. ⋯ Ovarian and incremental adrenal suppression did not fully suppress progestogen and androgen production in all of the study patients with 21-OH-deficient NCAH, suggesting that their production was partially independent of ACTH stimulation. Potentially in these patients subtle degrees of adrenocortical hyperplasia and/or abnormal enzymatic kinetics are responsible for the nonsupressibility.