Ulus Travma Acil Cer
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Ulus Travma Acil Cer · Sep 2017
Evaluation of the systemic antiinflammatory effects of levosimendan in an experimental blunt thoracic trauma model.
Blunt thoracic injury often leads to pulmonary contusion and the development of acute respiratory distress syndrome, which carries a high risk of morbidity and mortality, originating from the local and systemic inflammatory states. This study aimed to investigate the local and systemic antiinflammatory effects of levosimendan in rat models of blunt chest trauma. ⋯ In conclusion, the results showed that in a rat model of PC, the experimental agent levosimendan could reduce neutrophil cell infiltration to damaged pulmonary tissues and the systemic expressions of some cytokines (IL-1ß, IL-6, and NO), thereby partially reducing and/or correcting pulmonary damage. Systemic inflammatory response that occurs after trauma could also be reduced.
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Ulus Travma Acil Cer · Sep 2017
Evaluation of different treatment protocols for combined injury-induced lung injury in rabbits.
This study aims to evaluate the effectiveness of different treatment regimens on combined injury-induced lung injury. ⋯ This study demonstrated the impact of fluid resuscitation on combined injury-induced lung injury. Further, 1:3 fluid resuscitation treatment at the early stage of lung injury after combined lung contusion and burn injury was found to be more effective.