Neurochirurgie
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The insula is the only cortical part of the brain that is not visible on the surface of the hemisphere, because it is totally covered by the frontoparietal and temporal opercula. The insula is triangular in shape and is separated from the opercula by the anterior, superior, and inferior peri-insular sulci. It is morphologically divided into two parts by the central insular sulcus. ⋯ The literature contains no reports of cases of resection of insular cortex alone; most insular resections are performed in the context of temporal resection, when there is some evidence of seizures originating in the insula itself. Such procedures are risky and their efficacy, in terms of postoperative surgical outcome, has not yet been clearly assessed. In this context, less invasive procedures, such as SEEG-guided radiofrequency thermolesions of the insular cortex, are under investigation.
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Temporal lobe epilepsy (TLE) is the most common form of intractable partial epilepsy in adults. Surgery (lobectomy or amygdalohippocampectomy) is effective in most patients. However, some complications can occur and brain shift, hematoma into the post operative cavity and occulomotor nerve palsy have been reported due to the surgical technic. ⋯ In the seizure-free patient group, postoperative EEG showed interictal temporal spikes at three months, one year and two years located in the anterior temporal region. Temporal disconnection is effective, prevents the occurrence of subdural cyst and hematomas in the temporal cavity, prevents the occurrence of oculomotor palsy, and limits the occurrence of quadranopsia. However, comparative studies are required to evaluate temporal disconnection as an alternative to lobectomy in nonlesional TLE.
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Peri-insular hemispherotomy is a surgical technique used in the treatment of drug-resistant epilepsy of hemispheric origin. It is based on the exposure of insula and semi-circular sulci, providing access to the lateral ventricle through a supra- and infra-insular window. From inside the ventricle, a parasagittal callosotomy is performed. ⋯ Peri-insular hemispherotomy provides a functional disconnection of the hemisphere with minimal resection of cerebral tissue. It is an efficient technique with a low complication rate. Intra-operative EEG monitoring might be used as a predictive factor of completeness of the disconnection and consequently, seizure outcome.
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Taylor-type focal cortical dysplasias (TTFCD) represent a particular pathological entity responsible for severe drug-resistant epilepsy of extratemporal location. Epilepsy can be surgically cured if complete removal of the lesion can be performed. However, identification on imaging may be difficult and negative standard MRIs are not rare. The frequent location of TTFCD in the central region restrains the possibilities of complete resection. We report a series of patients operated on for intractable epilepsy associated with TTFCD in the central area. ⋯ This study suggests that surgical resection of central region TTFCD may be associated with favorable seizure outcome and no or minor functional permanent disability. In cases of seizure relapse, reoperation can be performed without further permanent deficit and lead to seizure-free outcome. Future techniques for intraoperative detection of these lesions could optimize their complete resection in functional areas.
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In many patients with drug-resistant partial epilepsy, depth electrode recordings may be required to delineate the best region for cortical resection. We usually implant depth electrodes according to Talairach's stereoelectroencephalography (SEEG) methodology. Using these chronically-implanted depth electrodes, it is possible to generate radiofrequency (RF) thermolesions of the epileptic foci and networks. ⋯ Twenty patients underwent conventional cortectomy in a second step, 18 of whom are in Engel class I. In conclusion, SEEG-guided RF-thermolesions of the epileptic foci and networks proved to be a safe therapeutic procedure capable of providing an immediate benefit in terms of seizure control, especially in patients with epilepsy symptomatic of cortical development malformation. Such thermolesions do not preclude subsequent conventional surgery in case of failure, which can be proposed as an alternative procedure if no resective surgery is possible.