Neurochirurgie
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Management of unresectable progressive meningioma remains controversial and constitutes a major challenge since therapeutic options including chemotherapy and hormone modulation are limited. Recent data have suggested that hydroxyurea treatment may have an antitumoral effect. The purpose of this prospective phase II study was to evaluate the efficacy of hydroxyurea treatment for unresectable progressive meningioma. ⋯ Hydroxyurea treatment is of marginal efficacy for meningioma and must not be considered as an alternative if radiotherapy or surgery is feasible. New efficient medical treatments are still required for progressive meningiomas.
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Randomized Controlled Trial Multicenter Study Clinical Trial
Neuroprotective effect of gacyclidine. A multicenter double-blind pilot trial in patients with acute traumatic brain injury.
The aim of this study was to assess the safety and efficacy of intravenous (IV) injections of gacyclidine, a novel NMDA receptor antagonist, for neurological and functional recovery following acute traumatic brain injury. This multicenter, prospective, randomized, placebo-controlled, double-blind study compared four parallel groups. Two IV doses were administrated (placebo, 2x0.005mg/kg, 2x0.001mg/kg, 2x0.02mg/kg): the first dose was given within 2 hours following the trauma, and the second dose 4 hours after the first. ⋯ Concerning efficacy, the predefined prognostic factors (initial CT-scan score, initial Glasgow Coma Scale and occurrence of low systolic blood pressure during the first 24 hours) largely determinated the patient's outcome. When the prognostic factors were taken into account together with the dose level in a logistic regression model, gacyclidine showed a beneficial long-term effect and a best dose-result in the 0.04mg/kg treated group. Data obtained in this clinical trial appeared sufficient to warrant a European multicenter study on gacyclidine using the same evaluation criteria and ICP monitoring.
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To propose an alternative to the sitting position and the other horizontal positions while maintaining the advantages of the sitting position and assuring maximum safety for the patient particularly with respect to the risk of air embolism. POSITION: The patient is positioned as for the sitting position with the median axis of the posterior cranial fossa prolonging the spinal axis. The head is maintained by a Mayfield head holder and is inclined without force. The patient rests laterally on the apron, the thorax and the lower limbs resting on cushions. The upper limbs rest on the arm rests interdependent with the table facilitating surgical access and rolling movements. ⋯ Since discontinuing use of the sitting position in our institution, we have found that the ventrolateral position can replace the sitting position advantageously. It allowed us to approach lesions located in a large area, from the cervical spine to the supratentorial area located behind external auditory meatus, and was compatible with anesthetic and surgical requirements.