Minerva anestesiologica
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Minerva anestesiologica · Sep 2020
Donation after circulatory death: possible strategies for in-situ organ preservation.
Donation after circulatory death (DCD) is an accepted strategy to expand the potential donor pool. The complexity of organ procurement from DCD donors requires the development of new strategies for organ preservation. Standard DCD organ recovery involves a super rapid technique, with cold thoracic and abdominal perfusion. ⋯ New strategies designed to improve the preservation of in-situ DCD grafts include the use of normothermic regional perfusion (NRP) for abdominal organs and concomitant cold lung flushing. The use of in-situ NRP is a significant advance in abdominal organ retrieval and it has the potential to increase organ recovery rates due to its applicability in both controlled and uncontrolled DCD donors. We describe an innovative preservation strategy based on the combination of donor NRP for abdominal organ preservation and a normothermic open-lung approach with protective mechanical ventilation for lung preservation.
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Minerva anestesiologica · Sep 2020
High neutrophil-to-lymphocyte ratio is associated with poor clinical outcome in patients with critically ill stroke.
This study aimed to evaluate the relationship between inflammatory markers on admission and clinical outcome in patients with critically ill stroke. ⋯ Inflammatory markers like NLR, LMR and CAR on admission were associated with increased risks of 30-day mortality and 90-day poor outcome in patients with critically ill stroke. Especially, high NLR is independently associated with 90-day poor outcome.