The Journal of pediatrics
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The Journal of pediatrics · Jan 2016
Randomized Controlled Trial Multicenter StudyImpact of Continuous Capnography in Ventilated Neonates: A Randomized, Multicenter Study.
To compare the time spent within a predefined safe range of CO2 (30-60 mmHg) during conventional ventilation between infants who were monitored with distal end-tidal CO2 (dETCO2, or capnography) and those who were not. ⋯ Continuous dETCO2 monitoring improved control of CO2 levels within a safe range during conventional ventilation in a neonatal intensive care unit.
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The Journal of pediatrics · Jan 2016
Observational StudyEndotracheal Intubation in Neonates: A Prospective Study of Adverse Safety Events in 162 Infants.
To determine the rate of adverse events associated with endotracheal intubation in newborns and modifiable factors contributing to these events. ⋯ Adverse events are common in the neonatal intensive care unit, occurring in 4 of 10 intubations. The odds of an adverse event doubled with increasing number of attempts and quadrupled in the emergent setting. Quality improvement efforts to address these factors are needed to improve patient safety.
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The Journal of pediatrics · Jan 2016
Comparative StudyNot Just a Drop in the Bucket-Inversion of Oxymetazoline Nasal Decongestant Container Increases Potential for Severe Pediatric Poisoning.
Oxymetazoline is an over-the-counter nasal decongestant with potent alpha agonist properties. In overdoses as small as 1-2 mL, toxicity can be seen including bradycardia and respiratory depression. We demonstrated that inverting the container increased the volume delivered 20- to 30-fold compared with holding it upright in an in vitro model.