The Journal of pediatrics
-
The Journal of pediatrics · Mar 2006
Clinical TrialPilot study of milrinone for low systemic blood flow in very preterm infants.
To examine the hemodynamic effects of milrinone given prophylactically to very preterm infants at high risk of low superior vena cava (SVC) flow and to investigate the preliminary efficacy and safety of an optimal dose. ⋯ We used population pharmacokinetic modeling to develop an optimal dosing regimen for milrinone. The efficacy and safety in this novel preventative approach to circulatory support is encouraging but inconclusive. We do not recommend the use of milrinone in preterm infants outside a research setting.
-
The Journal of pediatrics · Feb 2006
Outcome after preterm delivery of infants antenatally diagnosed with congenital heart disease.
To determine outcome of delivery before 36 weeks gestation in babies diagnosed antenatally with serious congenital heart disease (CHD). ⋯ There is a very high morbidity and mortality rate in this group, particularly for those with extracardiac/karyotypic anomalies. This should be reflected in decisions over elective preterm delivery and when counseling parents.