The Journal of urology
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The Journal of urology · Apr 1999
Detection of circulating prostate specific antigen expressing prostatic cells in the bone marrow of radical prostatectomy patients by sensitive reverse transcriptase polymerase chain reaction.
The reverse transcriptase polymerase chain reaction (RT-PCR) assay for prostate specific antigen (PSA) expressing cells in the blood circulation has been under intense investigation since 1992. Although it has been suggested that this technology could be used as molecular staging for occult prostatic hematogenous metastases, we have been unable to confirm RT-PCR PSA positivity of peripheral blood to predict stage or recurrence in radical prostatectomy cases. We performed bone marrow RT-PCR PSA assay on a large cohort of radical prostatectomy cases and evaluate the use of this assay in improving prostate cancer staging and detecting early recurrence. ⋯ Bone marrow RT-PCR PSA positivity in this study did not predict pathological stage, grade or margin positivity as determined from whole mount prostate cancer specimens. Furthermore, no relationship with age, grade or serum markers and bone marrow RT-PCR PSA positivity was noted. However, bone marrow RT-PCR PSA was associated with early disease recurrence. Further studies and longer followup are warranted to define the metastatic potential of the PSA expressing cells in the bone marrow of prostate cancer patients.
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The Journal of urology · Apr 1999
Clinical TrialSupranormal renographic differential renal function in congenital hydronephrosis: fact, not artifact.
Children with unilateral hydronephrosis, who had been prospectively examined with diethylenetriaminepentaacetic acid (DTPA) and dimercapto-succinic acid (DMSA) renography, were evaluated to determine whether supranormal renographic differential renal function exists. ⋯ Supranormal renographic differential renal function does exist in congenital hydronephrosis and when found the kidneys are consistently enlarged. The position of supranormal renographic renal function in the management algorithm of hydronephrosis remains to be elucidated as it does not appear to be a benign prognostic factor.
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The Journal of urology · Apr 1999
Urological needs assessment for primary care practice: implications for undergraduate medical education.
The majority of graduating medical students will become primary care physicians. We discuss what urological topics primary care physicians need to know, proficiency in urological skills of primary care physicians and undergraduate urological curriculum recommendations that would serve the needs of primary care physicians. ⋯ Primary care physicians need to know and be proficient in many urological topics and skills. They need to know diagnostics better than staging and management information, and urological infectious topics better than urological cancers. They need to be proficient in physical examination, urinalysis interpretation, catheter insertion, circumcision and vasectomy. Undergraduate medical education should reflect these needs.
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The Journal of urology · Apr 1999
Biography Historical ArticleFrère Jacques Beaulieu: from rogue lithotomist to nursery rhyme character.
We discuss the history of Frère Jacques Beaulieu, a celebrated 17th century French lithotomist, and question the relationship of his name to a well-known nursery rhyme character. ⋯ Beaulieu was an early urologist who was the first to describe the lateral approach to perineal lithotomy. Unlike other lithotomists of the 17th century, he openly shared his surgical techniques and stimulated others to refine the procedure. Regardless of the exact derivation of the nursery rhyme, the name Frere Jacques will always be remembered in song.