The Journal of urology
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The Journal of urology · Mar 2001
Prevalence of prostatitis-like symptoms in a population based study using the National Institutes of Health chronic prostatitis symptom index.
The National Institutes of Health (NIH) chronic prostatitis symptom index was used to determine the prevalence of prostatitis-like symptoms among men (age 20 to 74 years) at risk in a community based study. ⋯ In our opinion this community based study using the new prostatitis symptom index confirms that chronic prostatitis-like symptoms are common.
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The Journal of urology · Mar 2001
Clinical TrialPercutaneous sacral nerve root neuromodulation for intractable interstitial cystitis.
We evaluated the efficacy of percutaneous sacral nerve root neuromodulation in women with refractory interstitial cystitis. ⋯ Women with intractable interstitial cystitis respond favorably to percutaneous sacral stimulation with significant improvement in pelvic pain, daytime frequency, nocturia, urgency and average voided volume. Permanent sacral implantation may be an effective treatment modality in refractory interstitial cystitis but further long-term evaluation is required.
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The Journal of urology · Mar 2001
Comparative StudyIdentification of effective retinoids for inhibiting growth and inducing apoptosis in bladder cancer cells.
Retinoids modulate the growth and differentiation of normal and malignant epithelial cells in vitro and in vivo, and inhibit bladder carcinogenesis in animal models. Retinoid analogs have been used in several clinical chemoprevention trials of superficial bladder cancer recurrence. There is a clear need to identify new effective retinoids and develop novel approaches for the chemoprevention and treatment of superficial bladder cancer. We investigated the effects of various retinoids on growth inhibition and apoptosis induction in bladder cancer cell lines. ⋯ The results demonstrate that 4HPR is the most potent growth inhibitor and apoptosis inducer of the retinoids tested. Lack of retinoic acid receptor beta expression may be responsible for cell resistance to all-trans-retinoic acid but not to the other retinoids.