Monatsschr Kinderh
-
Histamine is partly metabolized to a stabile metabolite N-methyl-histamine and excreted in the urine. We analysed the degradation of infused histamine and the N-methyl-histamine-excretion in atopic and normal individuals as in patients with a bronchoconstriction due to allergen/exercise challenge. N-methyl-histamine was determined by a newly developed radioimmunoassay. 60 controls and 38 atopic individuals were investigated. ⋯ Only an 0.1% rise of N-methyl-histamine was observed following an oral administration of histamine. Neither bronchial challenge with specific allergen nor physical exercise elicited significant changes of N-methylhistamine excretion. The secretion of N-methyl-histamine demonstrates the degradation of histamine in the circulation, the measurement oft this metabolite in the urine should be considered when analysing the cause of severe systemic allergic reaction as anaphylaxis but not asthma or atopic disposition.
-
The information available in sports medicine regarding the development of performance and maximum stress is presented for children and adolsecents, and the importance of age-appropriate sports for general health is also discussed. A description of the five main forms of stress on the motor system follows, i.e., coordination, flexibility, strength, speed, and endurance, and their effectos on the performance parameters boys and girls from childhood to adolescence. Data on cardiopulmonary-metabolic performance parameters are discussed for children and adolescents. ⋯ Precocious young people are physically capable of a higher performance level and can tolerate more stress than their normal counterparts or those with delayed development. With regard to the five forms of stress mentioned above, health questions related to the ability to tolerate stress and age-related levels of training are dealt with. The negative effects on health are considered with regard to the development of amenorrhea and a decrease in the mineral content of the skeletal system as a result of extensive endurance training.
-
A 2-year-old boy presented with severe lactic acidosis and ileus symptoms after 3 weeks of parenteral nutrition. Diagnosis of thiamine deficiency was made only when further complications had occurred. This case shows the importance of sufficient substitution of thiamine during parenteral nutrition. In lactic acidosis of unknown etiology thiamine deficiency must be considered.