Pediatr Crit Care Me
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Pediatr Crit Care Me · Mar 2005
Risk factors for extubation failure in mechanically ventilated pediatric patients.
To describe the incidence of extubation failure and its associated risk factors among mechanically ventilated children. ⋯ Extubation failure was more frequent among young infants who received prolonged ventilatory support and intravenous sedation, used CPAP, had impaired lung oxygenation, and required inotropic therapy.
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Pediatr Crit Care Me · Mar 2005
The effects of milrinone on hemodynamics in an experimental septic shock model.
To investigate the specific hemodynamic effects of the phosphodiesterase inhibitor milrinone in a rabbit model of septic shock in the absence of any other treatment. ⋯ Milrinone improves cardiac output and tissue perfusion in a rabbit model involving severe septic shock.
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Pediatr Crit Care Me · Mar 2005
Randomized Controlled Trial Comparative Study Clinical TrialTheophylline versus terbutaline in treating critically ill children with status asthmaticus: a prospective, randomized, controlled trial.
To compare the efficacy of theophylline, terbutaline, or theophylline combined with terbutaline treatment in critically ill children with status asthmaticus who are already receiving continuous nebulized albuterol and intravenous corticosteroids. ⋯ Theophylline, when added to continuous nebulized albuterol therapy and intravenous corticosteroids, is as effective as terbutaline in treating critically ill children with status asthmaticus. The addition of theophylline to baseline therapy is more cost-effective when compared with terbutaline alone or terbutaline and theophylline together. Theophylline should be considered for use early in the management of critically ill asthmatic children.
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Pediatr Crit Care Me · Mar 2005
Clinical TrialInterleukin-6, interleukin-8, and a rapid and sensitive assay for calcitonin precursors for the determination of bacterial sepsis in febrile neutropenic children.
Children with cancer often develop febrile illnesses after cytotoxic chemotherapy. Determining which children have serious bacterial infections in this vulnerable period would be valuable. We evaluated the ability of a rapid and sensitive assay for the concentration of calcitonin precursors (CTpr) as a sensitive diagnostic marker for bacterial sepsis in febrile, neutropenic children and determined the utility of measuring cytokines to improve the predictive value of this approach. ⋯ Our data show the utility of a rapid and sensitive assay for CTpr combined with interleukin-8 as a highly sensitive and specific diagnostic marker of bacterial sepsis in febrile, neutropenic children. The use of these markers as a clinical tool may allow for better prognostication for clinicians and may eventually lead to more targeted therapies for this heterogeneous population.