Pediatr Crit Care Me
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The purpose of this review is to provide background and a concise set of definitions for pediatric surgical site and wound infections. ⋯ Although surgical site and wound infections rarely lead to intensive care unit admissions, definitions are still valuable for stratifying potential candidates for sepsis trials.
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Pediatr Crit Care Me · May 2005
ReviewConcept of PIRO as a new conceptual framework to understand sepsis.
To define and introduce the PIRO model for categorizing sepsis in infants and children. ⋯ The PIRO model is a conceptual framework for understanding sepsis that has many favorable attributes. The PIRO model should be directly tested in both the research laboratory and in clinical trial designs to determine the practical value and clinical relevance of this new classification scheme for sepsis.
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Pediatr Crit Care Me · May 2005
Review Comparative StudyCentral venous catheter use in the pediatric patient: mechanical and infectious complications.
Following the introduction and widespread use of central venous catheters (CVCs) in adults, these devices are being used with increasing frequency in the pediatric population. This review will focus on differences between adults and children regarding CVC use and its potential complications. Both mechanical and infectious complications will be discussed. ⋯ CVC-related complications in pediatric patients are closely linked to age, body size, and age-related immune status. In older children, many complications are similar to those encountered in adult patients. Because of ongoing growth and body changes, a cutoff point beyond which children can be regarded as "young adults" is difficult to define; many of our recommendations are therefore age-related. More frequently than in adults, an implanted port may be the first choice in pediatric patients when long indwelling times are expected. The optimal site of insertion also depends on factors such as the patients' age as well as the need for sedation and analgesia during the insertion procedure. In contrast to guidelines in adult patients, we recommend that a radiograph always be made following CVC insertion to check the position of the catheter. Regarding prevention of infectious complications, we recommend full sterile barrier precautions during CVC insertion and strict protocols for catheter care. CVCs should be removed as soon as possible when they are no longer needed, but there is no place for elective CVC replacement on a routine basis. New developments such as the use of impregnated catheters might help reduce infection rates; however, additional research will be required to provide more evidence of benefit in the pediatric population.
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To define pneumonia in critically ill children in the intensive care unit setting for surveillance of infection and for the design, conduct, and evaluation of clinical trials in the prevention and therapy of lower respiratory tract infections in this population. ⋯ Although pneumonia is one of the most common diagnoses in critically ill children, there have been few studies validating diagnostic criteria. Definitions for definite, probable, and possible community-acquired pneumonia and nosocomial pneumonia were achieved by consensus of experts based on guidelines from governmental agencies, professional organizations, and published literature. Future research should determine the utility of these definitions in the critically ill child and adapt them accordingly.
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Pediatr Crit Care Me · May 2005
ReviewWhat have we learned from observational studies on neonatal sepsis?
To assess how observational studies on neonatal sepsis can help define the knowledge base required for neonatal randomized, clinical trials. ⋯ Future observational studies must address three key issues. They should begin with a clear analytic and sampling plan that pays careful attention to the proper use and reporting of multivariate analyses. Second, they must explicitly address two subpopulations: critically ill newborns with negative cultures and asymptomatic newborns with positive cultures. Finally, they should be theory driven and provide empirical physiologic data that permit situating their results in the context of the evolving systemic inflammatory response syndrome and PIRO (predisposition, infection, host response, organ dysfunction) models.