British medical bulletin
-
British medical bulletin · Jan 2013
ReviewThe angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential.
Blood vessel formation is fundamental to development, while its dysregulation can contribute to serious disease. Expectations are that hundreds of millions of individuals will benefit from therapeutic developments in vascular biology. MSCs are central to the three main vascular repair mechanisms. ⋯ Characterization of MSCs' in vivo origins and biological properties in relation to their localization within tissue niches, reprogramming strategies and newer imaging/bioengineering approaches.