British medical bulletin
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British medical bulletin · Jun 2015
Review Meta AnalysisNo difference between unicompartmental versus total knee arthroplasty for the management of medial osteoarthtritis of the knee in the same patient: a systematic review and pooling data analysis.
One-third of patients with knee osteoarthritis (OA) has involvement of only one compartment, especially the medial one. ⋯ Large, multicentre, powered, randomized trials comparing UKA and TKA are needed to identify the best management for medial OA of the knee. Moreover, new score systems for satisfaction of the patient should be formulated.
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British medical bulletin · Jun 2015
ReviewPhenoxy herbicides, soft-tissue sarcoma and non-Hodgkin lymphoma: a systematic review of evidence from cohort and case-control studies.
Phenoxy herbicides have been used widely in agriculture, forestry, parks and domestic gardens. Early studies linked them with soft-tissue sarcoma (STS) and non-Hodgkin lymphoma (NHL), but when last reviewed by the International Agency for Research on Cancer in 1986, the evidence for human carcinogenicity was limited. ⋯ Extended follow-up of previously assembled cohorts may be the most efficient way of further reducing uncertainties.
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British medical bulletin · Jun 2015
ReviewReinventing clinical trials: a review of innovative biomarker trial designs in cancer therapies.
Recently, new clinical trial designs involving biomarkers have been studied and proposed in cancer clinical research, in the hope of incorporating the rapid growing basic research into clinical practices. ⋯ Biomarker-related trial designs that can resolve the statistical issues and satisfy the regulatory requirement.
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British medical bulletin · Jun 2015
ReviewAutoimmune hepatitis: an approach to disease understanding and management.
Autoimmune hepatitis is a chronic immune-mediated liver injury, frequently associated with progression to end-stage liver disease if untreated. Patients commonly present with hepatitis, positive immune serology, elevated immunoglobulins and compatible liver histology, in the absence of an alternative aetiology. ⋯ Increased understanding of the immunoregulatory mechanisms behind autoimmune hepatitis has led to opportunities for new therapies. These are developed including a discussion of timely research studies relevant to future therapies for patients.
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Biobanking refers to the infrastructure, policies and practices involved in collecting, processing, storing and disseminating biological samples. Biospecimen methods research to support biobanking through evidence-based practices is now recognized as critical to the success of biobanking and translational research. ⋯ Additional biospecimen methods research leading to the development of evidence-based practices is critical to translational research and personalized medicine.