British medical bulletin
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Genomic science is developing rapidly, and engagement of public health professionals will be necessary to appraise new technologies and use them effectively. ⋯ Public health researchers should address how to accelerate the implementation of genomics for health benefit in developed and developing countries.
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British medical bulletin · Dec 2014
ReviewHigh-resolution imaging of bone and joint architecture in rheumatoid arthritis.
Rheumatoid arthritis (RA) is characterized by local and systemic bone loss caused by increased bone resorption. We describe the current utilization of high-resolution peripheral quantitative computed tomography (HR-pQCT) in the evaluation of bone and joint in RA. ⋯ Although HR-pQCT is currently a research tool, there is potential for its use in the clinical diagnosis and management in RA. Further research is required to evaluate the clinical relevance of imaging abnormalities identified in RA patients.
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British medical bulletin · Dec 2014
ReviewCare of the dying: how do we replace the Liverpool Care Pathway?
Death is an inescapable certainty of life. Variability in care for dying persons, however, is present. The Liverpool Care Pathway (LCP) sought to guide care for the last days of life but was phased out after intense scrutiny. ⋯ Perceptions of relevant terminology; review of the definition of dying; improved recognition of the dying process and measuring the impact of communication skills training.
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British medical bulletin · Dec 2014
ReviewThe molecular genetics of hereditary and sporadic ovarian cancer: implications for the future.
Epithelial ovarian cancer (EOC) is a heterogeneous condition with poor survival outcomes. The genetics of hereditary and sporadic ovarian cancers will be covered and its implications to management and future research are discussed. ⋯ Given how heterogeneous 'ovarian' cancer is, trials into new drugs should report responses for the different histo-/geno-types rather than simply using staging. Although the effect of new drugs such as poly(ADP-ribose) polymerase inhibitors are being investigated in ovarian cancer, there is still a need to develop targeted therapies-especially to tackle mutations in PI3 K pathway, RAS pathway and TP53.
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British medical bulletin · Sep 2014
ReviewThe importance of pain management in older people with dementia.
Pain is common in people with dementia, representing a critical aspect of treatment and care. However, there remain considerable gaps in evidence to support pain assessment and treatment. ⋯ Future research should focus on developing integrated pain management approaches with optimized assessment and evidence-based treatment guidance.