No shinkei geka. Neurological surgery
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Cerebral vasospasm following subarachnoid hemorrhage (SAH) is one of the most important problems in the treatment of ruptured intracranial aneurysms. Several reports have recently emphasized that oxyHb from erythrocytes might be responsible for vasospasm. In this study, the hem-oxygenase which converts oxyHb to bilirubin was analyzed and the increase of hem-oxygenase in the CSF after SAH was reconfirmed. ⋯ As a result, 2 (9%) of the 23 patients treated with the drainage showed symptomatic vasospasm. On the other hand, 13 (33%) of 39 patients without the drainage showed symptomatic vasospasm. It may be concluded that the drainage may contribute to prevention of cerebral vasospasm after SAH.