Arch Iran Med
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Breast cancer is the major cause of death from cancer among women around the world. Given the drug resistance in the treatment of this disease, it is very important to identify new therapies and anticancer drugs. Many studies demonstrated that hypericin could induce apoptosis in different cancer cell lines; however, the underlying mechanism is not well understood yet. Therefore, this study aimed to evaluate the anticancer effect of hypericin in two breast cancer cell lines, one with wild type P53 and the other with mutant P53. ⋯ The results of this study demonstrated that hypericin's apoptotic and cytotoxic effects on cancer cells may be mediated via P53 overexpression, cell cycle arrest and the subsequent apoptosis. Therefore, it is of great importance to consider that hypericin would have better impact on cells or tumors with wild type P53.
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Chronic infection with hepatitis C virus (HCV), can now be safely treated with oral, well-tolerated medications with >90% success rates, however, currently <5% of the infected individuals have been diagnosed and <1% have received treatment. This is believed to be due to the complicated, time-consuming and expensive disease management processes that require several referrals to specialized laboratories and hospital-based clinics, and also the epidemic of HCV infection among populations who have low uptake for evaluation, appointments, and treatment. ⋯ Furthermore, successful implementation of this policy requires acceptability from the perspectives of healthcare providers, target populations, and policymakers. In this letter, we discuss the current applicability, acceptability, and cost-effectiveness of POC policy for the management of HCV infection.