Chinese Med J Peking
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Chinese Med J Peking · Sep 2010
Randomized Controlled Trial Comparative StudyA comparison between vital capacity induction and tidal breathing induction techniques for the induction of anesthesia and compound A production.
Vital capacity induction and tidal breathing induction are currently administered for inhalation induction of anesthesia with sevoflurane. The aim of this study was to compare them using sevoflurane with respect to induction time, complications of inhalation induction, and compound A production in adult patients. ⋯ For inhalation induction of anesthesia, the vital capacity induction was faster and produced fewer complications than that for tidal breathing induction, but increased compound A production in the circuit system.
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Chinese Med J Peking · Sep 2010
Clinical TrialPopulation pharmacokinetics of rocuronium delivered by target-controlled infusion in adult patients.
Target-controlled infusion (TCI) has been recently developed and successfully implemented in clinical practice. The current study was to estimate the population pharmacokinetics of rocuronium TCI in adult patients using nonlinear mixed-effects model (NONMEM), and to investigate the influence of relevant factors in adult patients. ⋯ No pharmacokinetic change was noted when rocuronium was administered via TCI. Both age and weight as covariates affected the pharmacokinetic parameters.
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Chinese Med J Peking · Sep 2010
Emergence of Klebsiella pneumoniae carbapenemase-producing Proteus mirabilis in Hangzhou, China.
Carbapenems are used to treat severe infections caused by multi-drug-resistant organisms, however, the emergence of carbapenem-resistant bacterial isolates is becoming an increasing therapeutic challenge. Since the first Klebsiella (K.) pneumoniae carbapenemase (KPC)-producing K. pneumoniae was reported in 2001, KPC-producing isolates have been found increasingly, specially in Enterobacteriaceae. The aim of this study was to characterize the mechanisms of a carbapenem-resistant Proteus (P.) mirabilis. ⋯ Carbapenem resistance in the P. mirabilis isolate in this study is mainly due to production of KPC-2.