J Res Med Sci
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Previous studies have inspected the associations between Adiponectin (ADIPOQ) 276G/T polymorphisms and atherosclerosis, but the results are inconclusive. The aim of this study was to explore the relationship between polymorphism +276 G > T (rs1501299) in ADIPOQ and atherosclerosis. A widespread search was directed to identify all studies on the association of ADIPOQ 276G/T polymorphism with atherosclerosis risk. ⋯ Furthermore there was no evidence of publication bias in the meta-analysis. The present meta-analysis showed that there is no association between ADIPOQ 276G/T polymorphism and atherosclerosis. High quality studies are still needed to add for more investigation of the association between ADIPOQ 276G/T polymorphisms and atherosclerosis.
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Ketamine, a non-competitive NMDA (N-Methyl-D-Aspartate) receptor antagonist, is recognized as an intraoperative anesthetic agent. Increasing interest in the use of low-dose ketamine for postoperative analgesia has developed in part because of its NMDA-antagonistic properties, which may be important in attenuating central sensitization and opioid tolerance. Despite of many trial evaluations which have been done on the effect of low-dose ketamine in postoperative pain, the role of ketamine, as a component of perioperative analgesia, remains unclear. We evaluated the analgesic effect of low-dose ketamine during anesthesia induction in painful ophthalmic surgery. ⋯ This study demonstrates that a low dose administration of ketamine during anesthesia induction in retinal detachment, strabismus, and keratoplasty surgery improves the extubation time but have no effect on postoperative pain, nausea and vomiting, and perioperative additional analgesic requirements.
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The aim of this study was to compare the postoperative pain scores and morphine requirements between spinal anesthesia (SA) with hyperbaric bupivacaine 0.5% and general anesthesia (GA) with 1 Minimal alveolar concentration minimal alveolar concentration (MAC) of isoflurane in 50% N2O and O2 after elective lower abdominal surgery. ⋯ Although in patients undergoing elective lower abdominal surgery with SA may have lower pain scores and also lower morphine requirement in the first 6 h postoperatively, but after that there were no significant differences between SA and GA regarding postoperative pain scores and analgesic requirements and so more attention should be given to their postoperation pain relief.
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We investigated the difference of clinical practice pattern between end-stage chronic obstructive pulmonary disease (COPD) patients with and without palliative care at the end of life in Taiwan. ⋯ Palliative care was underutilized and referral was delayed for COPD patients. COPD patients are polysymptomatic approaching the end of life and this characteristic should be taken into account in providing appropriate end-of-life care in the same way as for cancer patients. Palliative care for COPD patients is urgently needed in Taiwan and should be promoted.