Med Klin
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Chemotherapeutic options in the treatment of advanced colorectal cancer have markedly improved during the last years. This is partly due to the high-dose 5-FU regimen, but also to the development of new cytotoxic agents and drug combinations. ⋯ Prospective randomized phase III trials must confirm the best chemotherapy and the best strategy for the different subgroup of patients.
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Explicit data on the quality of health care in addition to economic data represent major instruments of internal as well as external controlling and resource allocation. ⋯ Issues of further discussion are loss of validity of indicators due to awareness and alteration of documentation habits, public disclosure, and the evaluation of indicators by means of evidence-based medicine.