Presse Med
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Review
[Anti-inflammatory non-steroidal selective cyclooxygenase 2 inhibitors and gastroduodenal lesions].
NSAID CATEGORIES: Contrary to classical NSAIDs, which inhibit the 2 isoforms of cyclo-oxygenase (COX), coxibs do not affect COX-1, which catalyses the synthesis of cytoprotective prostaglandins in the stomach.
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Neonatal lupus erythematosus is a rare syndrome (affecting 5% of the children born of mothers with lupus), characterized essentially by cutaneous lesions and/or congenital auricular-ventricular heart block. It is due to the transplacental passage of maternal antibodies (anti-SSA or anti-SSB, or occasionally anti-U1RNP antibodies) into the fetal circulation. ⋯ Cutaneous lesions can also appear after the 4th week of life. It is important that the pediatricians clinically monitor all the children born to mothers exhibiting anti-SSA or anti-SSB antibodies, at least during the first 7 months of life.
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GRAPEFRUIT: Essentially consumed in the form of juices with its bitterness helping to quench thirst, grapefruit contains not only vitamin C but also many complex antioxidizers, licopene, lemonoids and naringine. It also contains large quantities of pectin. Grapefruit juice is a metabolic inhibitor of medicinal substances that constitute an exclusive target for the CYP 3A4 isozyme and glycoprotein P in the enterocytes. ⋯ The potential occurrence of side effects with its use has led the European Agency for drug assessment and the French Medicines Agency to decree that all magistral preparations containing St. John's wort must be labeled: "Warning, risk of drug interactions". GARLIC: (Allium salivum) Originating from Asia, widespread and cultivated in Europe in kitchen gardens, garlic is used by herbalists for its diuretic, antiseptic, stimulating and sudorific properties.