Neurology
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Randomized Controlled Trial Multicenter Study
Efficacy and safety of eptinezumab in patients with chronic migraine: PROMISE-2.
To evaluate the efficacy and safety of eptinezumab, a humanized anti-calcitonin gene-related peptide monoclonal antibody, in the preventive treatment of chronic migraine (CM). ⋯ NCT02974153.
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To describe and compare phenotypic features of posttraumatic headaches (PTH) and headaches unrelated to concussion. ⋯ NCT01847040.
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Randomized Controlled Trial
Noninvasive vagus nerve stimulation and the trigeminal autonomic reflex: An fMRI study.
The trigeminal autonomic reflex is a physiologic reflex that plays a crucial role in primary headache and particularly in trigeminal autonomic cephalalgias, such as cluster headache. Previous studies have shown that this reflex can be modulated by the vagus nerve, leading to an inhibition of the parasympathetic output of the reflex in healthy participants. The aim of the present study was to characterize neural correlates of the modulatory effect of noninvasive vagus nerve stimulation (nVNS) on the trigeminal autonomic reflex. ⋯ These findings indicate a complex network involved in the modulatory effect of nVNS including the hypothalamus, the sTN, the pontine nucleus, and the parahippocampal gyrus.