Neurology
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Interrelationships among the MTHFR 677C>T polymorphism (rs1801133), migraine, and cardiovascular disease (CVD) are plausible but remain controversial. ⋯ Data from this large cohort of women suggest a modest protective effect of the MTHFR 677TT genotype on migraine with aura. The increased risk for cardiovascular disease among migraineurs with aura was magnified for TT genotype carriers, which was driven by a substantially increased risk of ischemic stroke.
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To assess the prognostic implications of both the absolute spike frequency over the affected temporal lobe and the relative spike distribution between the two temporal lobes (i.e., uni- vs bitemporal spike distribution) for postoperative seizure control in a series of consecutive patients with medically refractory mesial temporal lobe epilepsy (MTLE) and MRI evidence of unilateral hippocampal atrophy (HA). ⋯ This study identified absolute preoperative spike frequency as a strong predictor for surgical outcome, while relative spike distribution had no significant influence on postoperative seizure control.