Pediatric clinics of North America
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Pediatr. Clin. North Am. · Aug 2018
ReviewChronic Nonbacterial Osteomyelitis and Chronic Recurrent Multifocal Osteomyelitis in Children.
Chronic nonbacterial osteomyelitis (CNO) is an innate immune system disorder that predominantly affects children. It can present as part of a syndrome or in isolation. It presents as bone pain with or without fever or objective swelling at the site. ⋯ Osteolytic or sclerotic bone changes may be seen on radiographs. However, MRI is more sensitive for detecting CNO and is considered the gold standard for monitoring the disease. Treatment depends on disease severity and includes nonsteroidal antiinflammatory drugs, bisphosphonates, and cytokine inhibitors.