Acta anaesthesiologica Belgica
-
Acta Anaesthesiol Belg · Jan 1988
Review Comparative StudyThe relevance of immunologic responses to anesthesia and surgery.
Out of some three million general anesthetic (GA) procedures administered in the UK each year some 10,000 patients will suffer clinically a severe immediate hypersensitivity-type (anaphylactoid) response: some will suffer neurological deficit, a few will die. The problems are essentially those intrinsic to all intravenous administration and infrequently drug specific. ⋯ The relative incidence of severe LA to GA reactions reported nationwide to Sheffield lies between 5% and 10% of the total reports. In the post-operative period the dramatic changes in laboratory parameters of immunity refer largely to the stress response to surgery and probably have little relevance to post-operative infection and wound healing in elective surgery.
-
Acta Anaesthesiol Belg · Jan 1988
Clinical Trial Controlled Clinical TrialA new lormetazepam galenical formulation for sublingual premedication.
This study reports a double-blind evaluation of a new formulation of lormetazepam for sublingual administration, given as a premedicant in 48 female patients undergoing minor gynecological procedures. Both patient's and nurse's assessments for anxiety and sedation were recorded at different times. ⋯ Nurses reported significant differences in sedation only, but already present at 30 minutes after premedication. The memory test showed no persistent effect of the benzodiazepine one day after surgery.
-
Acta Anaesthesiol Belg · Jan 1988
ReviewThe relevance of metabolic and endocrine responses to anesthesia and surgery.
The development of anesthesia has reached a stage where the evaluation of the usefulness of metabolic and endocrine responses is highly important. At present, these responses are commonly modulated in patients known to benefit most (e.g. patients with ischemic cardiovascular disease and patients undergoing major abdominal surgery), but no methods of totally response-free anesthesia and surgery are available, nor are there methods for the modulation of the responses on a wide clinical scale. Fortunately, in most patients undergoing conventional elective operations good anesthetic care is sufficient for blunting of the responses. Better methods of modulating the responses may be available in the future, which will greatly change anesthesia practice.