Middle East journal of anaesthesiology
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Middle East J Anaesthesiol · Feb 2001
Randomized Controlled Trial Clinical TrialThe use of low-dose rocuronium to facilitate laryngeal mask airway insertion.
In this two-phase study, the efficacy of low-dose rocuronium to facilitate laryngeal mask airway (LMA) insertion was evaluated. First, the onset time of 100, 150 and 300 micrograms.kg-1 rocuronium was determined using mechanomyography in three groups of patients (n = 10 in each) anaesthetized with propofol-fentanyl-nitrous oxide. In the second part, 100, 150 or 300 micrograms.kg-1 rocuronium or placebo was administered randomly to four groups of patients (n = 50 in each) in a double-blind manner. ⋯ LMA insertion was graded easy in 80% of patients who received 100 micrograms.kg-1 rocuronium. The incidence of unpleasant effects was greatest with 300 micrograms.kg-1 rocuronium. The optimal dose needed to facilitate LMA insertion with minimal unpleasant effects appeared to be 100 micrograms.kg-1 rocuronium.
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Middle East J Anaesthesiol · Feb 2001
Randomized Controlled Trial Clinical TrialSecond dose thiopentone attenuates the haemodynamic response to laryngoscopy and intubation.
The study was undertaken to evaluate the effectiveness of large (divided) thiopentone dosage on the peripheral haemodynamic response to laryngoscopy and intubation. Seventy-six (76) patient aged 18 to 67 years were sequentially assigned to either the second dose thiopentone group (n = 36) or the control group (n = 40). The first group had 4 mg.kg-1 thiopentone for induction of anaesthesia, then 1.5 mg.kg-1 suxamethonium chloride for muscle relaxation and a second dose of thiropentone (4 mg.kg-1) just before laryngoscopy and intubation. ⋯ The difference in the values represented the haemodynamic response to laryngoscopy and intubation. The second dose thiopentone technique compared with the control group, significantly attenuated the post-intubation rise in HR (19.7 vs. 30.9), SAP (18.0 vs. 37.5) and RPP (4795.4 vs. 8440.0). The post intubation rise in DAP (33.9 vs. 42.5) and MAP (31.9 vs. 42.0) didn't show significant difference between the two groups.
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Post-operative sore throat is a common minor complication after anesthesia. This paper reviews the factors which influence post-operative sore throat in intubated patients. Two hundred and sixty six intubated patients were investigated to find the incidence of sore throat after elective anesthesia in a middle eastern population. ⋯ Duration of anesthesia of greater than 90 minutes was associated with significant increase in sore throat (p < 0.001). Surgical factors including type of surgery, the use of throat packs and early oral intake did not alter the incidence of sore throat. Nasogastric tube insertion was associated with a significantly increased incidence of sore throat (p < 0.01).