Revista española de anestesiología y reanimación
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Rev Esp Anestesiol Reanim · Mar 1993
Clinical Trial Controlled Clinical Trial[Synergism of midazolam and propofol in the induction of anesthesia].
The purpose of this study was to determine the possible interaction of midazolam and propofol in the induction of anesthesia. ⋯ Propofol potentiates the action of midazolam in anesthetic induction. Although this synergism also reduces with the association of thiopental-midazolam, the mechanism of action is not demonstrated as the same. Thiopental increases the affinity of the benzodiazepines for the GABA complex receptors which has not been described for propofol.