Revista española de anestesiología y reanimación
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Rev Esp Anestesiol Reanim · Mar 1994
Comment Randomized Controlled Trial Comparative Study Clinical Trial[Oral premedication with clonidine in patients undergoing coronary revascularization surgery].
To analyze the effect of premedication with clonidine on level of sedation, anesthetic requirements and hemodynamic repercussions in patients undergoing coronary revascularization. ⋯ Use of clonidine in the type of patient studied does not improve the level of sedation over that achieved with lorazepam. Fentanyl requirements decreased with clonidine. With respect to hemodynamic profile, systemic vascular resistance fell in the clonidine group after removal of ECC, and thus this drug offers no advantages for routine premedication.
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Rev Esp Anestesiol Reanim · Mar 1994
Randomized Controlled Trial Comparative Study Clinical Trial[Comparative study between anesthesia by continuous perfusion with propofol or thiopental-isoflurane in laryngeal surgery].
To compare two anesthetic protocols for maintenance of anesthesia during laryngectomy (propofol vs thiopental-isoflurane), assessing its effects on intraoperative hemodynamic stability and recovery time after withdrawal of anesthesia. ⋯ Propofol for anesthetic maintenance is effective and safe. There are no differences in hemodynamic changes produced by propofol and isoflurane. Time until recovery of consciousness is longer with isoflurane, although we believe that this is not clinically relevant in this type of procedure.
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Rev Esp Anestesiol Reanim · Jan 1994
Randomized Controlled Trial Comparative Study Clinical Trial[Effects on the newborn infant of thiopental and propofol used in anesthetic induction in cesarean section].
To compare the effects of an anesthetic induction dose of thiopental to that of propofol on the vitality of the neonate, as measured by Apgar score and the interval between extraction of the newborn and unassisted respiration. ⋯ If the induction-extraction interval is 10 min or less, both thiopental (4 mg/kg) and propofol (2 mg/kg) given in a single dose for induction of general anesthesia in all types of cesarean section are equally safe for the newborn infant.
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Rev Esp Anestesiol Reanim · Jan 1994
Comparative Study[Speed of intubation using a new neuromuscular blocker. Rocuronium bromide (ORG 9426)].
To compare intubation conditions and neuromuscular parameters, patency time, maximum level of block, time and clinical duration of effect for rocuronium bromide 0.6 mg/kg (ORG 9426) versus equally potent doses of vecuronium and atracurium under similar experimental conditions. ⋯ Means of onset times and times of effect for rocuronium (33 and 135 sec) were significantly lower than those obtained with vecuronium and atracurium. Clinical duration, free of hemodynamic changes, was similar in the three groups. Rocuronium produces excellent intubation conditions 60 sec after administration, although at this point peripheral muscle block was only partial. Rocuronium may be superior to other neuromuscular blockers available today as a result of the speed with which it affords excellent intubation conditions.