Journal of the Medical Association of Thailand = Chotmaihet thangphaet
-
Randomized Controlled Trial Comparative Study
Femoral nerve block using 0.25% or 0.5% bupivacaine for analgesia after arthroscopic anterior cruciate ligament reconstruction.
Femoral nerve block (FNB) with varying concentrations of bupivacaine is often used for postoperative analgesia after anterior cruciate ligament (ACL) reconstruction. ⋯ FNB with 0.5% bupivacaine provided longer time to first analgesic and lower narcotic requirements after patellar tendon graft ACL reconstruction when compared to 0.25% bupivacaine. Both concentrations showed similar effect on quadriceps strengths.
-
Randomized Controlled Trial Comparative Study
Comparison of intrathecal bupivacaine, levobupivacaine for cesarean section.
Some investigators found a greater incidence of hypotension in patients receiving intrathecal hyperbaric solution than in patients receiving plain solution for cesarean section. ⋯ The level of absence of cold sensation, level of pinprick analgesia, and time to achieve sensory block to T4 level were statistically higher in patients receiving hyperbaric bupivacaine than in patients receiving plain bupivacaine and plain levobupivacaine, while the differences were not statistically significant in all groups regarding effective surgical anesthesia, postoperative analgesia, and side effects. Therefore, Levobupivacaine can be an alternative to bupivacaine.
-
Randomized Controlled Trial Comparative Study
Comparison of the effectiveness between generic and original form of gabapentin for pain relief in suspected neuropathic component of low back pain.
To compare effectiveness of the generic form of gabapentin with its original form. ⋯ In comparison with the GOF (Neurontin) group, the non-inferior effectiveness for pain reduction and improvement of back function has been revealed in the GGF (Gabapentin Sandoz) group. Similar safety profiles were demonstrated in both groups. The average medication cost of GGF is much lower than GOF (4.67 times).
-
Randomized Controlled Trial Comparative Study
A comparison of the combination of atropine and glycopyrrolate with atropine alone for the reversal of muscle relaxant.
Muscle relaxant is commonly used in general anesthesia to facilitate surgery. When finishing the operation, anesthesiologists reverse the muscle relaxant with anticholinesterase, neostigmine, combined with anticholinergic for prevention of unwanted side effects from neostigmine. The only existed anticholinergic in Thailand is atropine, which has a more rapid onset than neostigmine resulting in initial tachycardia. Lately, we have glycopyrrolate that cause less increase in initial heart rate. Therefore, we would like to study the effect of heart rate of the combination between atropine and glycopyrrolate to counteract the effect of neostigmine. ⋯ There is no significant different increase in heart rate in 0.2 mg glycopyrrolate plus 0.6 mg atropine group compared to 1.2 mg atropine alone for antagonizing muscarinic effects of 2.5 mg neostigmine. Therefore, atropine 0.6 mg and glycopyrrolate 0.2 mg is an alternative to antagonize muscarinic effects of neostigmine.
-
To determine the plasma concentrations of bupivacaine and toxicity after periarticular injection (PAI) combined with spinal anesthesia and femoral nerve block (FNB). ⋯ The plasma concentration of bupivacaine in patients performed periarticular injection with 20 ml of 0.25% bupivacaine after spinal anesthesia and single-shot femoral nerve block with 20 ml of 0.5% bupivacaine is below the plasma toxic level.