Journal of the Medical Association of Thailand = Chotmaihet thangphaet
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Deaths attributed to birth defects are a major cause of infant and under-five mortality as well as lifetime disabilities among those who survive. In Thailand, birth defects contribute to 21% of neonatal deaths. There is currently no systematic registry for congenital anomalies in Thailand. Queen Sirikit National Institute of Child Health has initiated a Thailand Birth Defects Registry to capture birth defects among newborn infants. ⋯ The present study established the Birth Defects Registry by collecting data from four databases in Thailand. Information obtained from this registry and surveillance is essential in the planning for effective intervention programs for birth defects. The authors suggest that this program should be integrated in the existing public health system to ensure sustainability.
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Mucopolysaccharidosis (MPS) can be classified into 7 types according to the enzyme defects. Several countries use enzyme replacement therapy (ERT) as treatment for types 1, 2 and 6. ERT is very expensive:--therefore, to determine if this treatment could be made available in Thailand, it is important to know the numbers of the patients with MPS. ⋯ MPS2 is the most common type of MPS in this study, followed by type 6 and 1. The difference in growth parameters seen in MPS2 suggest that it may be a factor in the development of MPS2.
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Randomized Controlled Trial Comparative Study
The safety of propofol infusion compared to midazolam and meperidine intravenous bolus for patients undergoing double balloon enteroscopy.
The double balloon enteroscopy (DBE) procedure is long and requires moderate sedation. We aim to determine whether the administration of propofol infusion is safe by comparing it to intravenous midazolam/meperidine in patients undergoing DBE. ⋯ Propofol infusion is safe and shows no difference in outcome from the midazolam and meperidine sedation for the DBE procedure.
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Randomized Controlled Trial
Oral rehydration with 10% carbohydrate drink for preventing postoperative nausea and vomiting (PONV) after low dose of spinal morphine.
Preoperative oral carbohydrate (CHO) drink may improve patients' comfort. However, whether it prevents or reduces postoperative nausea and vomiting (PONV) is questionable. ⋯ Preoperative oral rehydration with carbohydrate drinks had no positive effect on PONV nor patients' comfort.
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Infants who were readmitted with high level of bilirubin (more than 20 mg/dl) should be treated as an acute medical emergency to prevent acute and chronic bilirubin encephalopathy. ⋯ Initiating phototherapy within an hour of admission in infants who were readmitted with high levels of bilirubin is effective to prevent bilirubin encephalopathy. Physicians' early recognition of the risk factors to exchange transfusion is, therefore, crucial.