Journal of opioid management
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Case Reports
A remifentanil/ketamine sedation in surgical cancer patients having severe Parkinson's disease: two case reports.
Symptoms of Parkinson's disease are related to a progressive loss of substancia nigra's dopaminergic neurons in addition to persistent activation of N-methyl-D-aspartate receptors. In specific situations such as sedation for minor surgery, tremor and dyskinesia can be very disabling. ⋯ The patients were scheduled for elective oncological plastic surgery under sedation, for which dyskinesia and tremor needed to be quickly abolished to permit surgery. Both procedures were completed with this drug combination resulting with no major side effects.
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To describe dosing regimens and efficacy of continuous infusion hydromorphone in mechanically ventilated children. ⋯ Continuous infusion hydromorphone appears to be an effective adjunctive analgesic in mechanically ventilated children.