The Lancet. Respiratory medicine
The most recent articles from:
Lancet Respir Med
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Comment Letter
Non-invasive positive pressure ventilation for severe COPD.
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Comment Letter
Non-invasive positive pressure ventilation for severe COPD.
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Randomized Controlled Trial Multicenter Study
Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial.
Evidence is weak for the ability of long-term non-invasive positive pressure ventilation (NPPV) to improve survival in patients with stable hypercapnic chronic obstructive pulmonary disease (COPD). Previous prospective studies did not target a reduction in hypercapnia when adjusting ventilator settings. This study investigated the effect of long-term NPPV, targeted to markedly reduce hypercapnia, on survival in patients with advanced, stable hypercapnic COPD. ⋯ German Lung Foundation; ResMed, Germany; Tyco Healthcare, Germany; and Weinmann, Germany.