Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC
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J Obstet Gynaecol Can · Jul 2018
Ondansetron in Pregnancy and the Risk of Congenital Malformations: A Systematic Review.
Ondansetron, not approved for use in pregnancy, is increasingly being prescribed for nausea and vomiting in pregnancy and hyperemesis gravidarum. A number of recent lawsuits have highlighted the possibility that ondansetron may cause congenital malformations. The aim of this study was to systematically review epidemiological evidence on the potential association of prenatal exposure to ondansetron and congenital malformations. ⋯ While further investigation of the literature is needed, our results highlight the paucity of evidence linking prenatal exposure to ondansetron to an increased risk of congenital malformations. There is a need for additional epidemiologic studies to confirm whether ondansetron represents a safe and effective alternative treatment for nausea and vomiting in pregnancy and hyperemesis gravidarum.
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J Obstet Gynaecol Can · Apr 2018
Comparative StudyLaparoscopic and Robotic-Assisted Hysterectomy for Uterine Leiomyomas: A Comparison of Complications and Costs.
Robotic surgery is increasingly being used for treatment of malignant and benign gynaecologic diseases. The purpose of our study is to compare patient perioperative complications and costs of laparoscopic versus robotic-assisted hysterectomy for uterine leiomyomas. ⋯ While there are only slight differences in postoperative complications between laparoscopic-assisted hysterectomy and robotic-assisted hysterectomy, robotic-assisted hysterectomy is associated with considerably greater direct costs. Unless specific indications for robotic-assisted hysterectomy exist, laparoscopic-assisted hysterectomy should be the preferred approach for minimally invasive surgical treatment of leiomyomas.
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J Obstet Gynaecol Can · Apr 2018
Practice GuidelineNo. 358-Intravaginal Laser for Genitourinary Syndrome of Menopause and Stress Urinary Incontinence.
This technical bulletin reviews the evidence relating to risks and benefits of using intravaginal laser technology in the management of genitourinary syndrome of menopause and stress urinary incontinence. ⋯ RECOMMENDATIONS.
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J Obstet Gynaecol Can · Feb 2018
Practice GuidelineNo. 129-Exercise in Pregnancy and the Postpartum Period.
To design Canadian guidelines advising obstetric care providers of the maternal, fetal, and neonatal implications of aerobic and strength-conditioning exercises in pregnancy. ⋯ This guideline has been jointly sponsored by The Society of Obstetricians and Gynaecologists of Canada and the Canadian Society for Exercise Physiology.
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J Obstet Gynaecol Can · Dec 2017
Practice GuidelineNo. 353-Treatments for Overactive Bladder: Focus on Pharmacotherapy - An Addendum.
This technical update addendum reviews success rates and comparative evidence of the anticholinergic fesoterodine, as well as mechanism of action, safety profile, success rates, and comparative evidence of the β3 agonist mirabegron in the treatment of non-neurogenic overactive bladder syndrome (OAB). This adds to OAB pharmacotherapy recommendations initially published in 2012. ⋯ Not applicable.