Läkartidningen
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Postoperative nausea and vomiting (PONV) continues to be a clinical problem with an unacceptably high incidence. Several studies have been performed that compare different antiemetics but thus far no successful monotherapy has been found. ⋯ In patients at great risk it is meaningful to recommend prophylactic antiemetics with a 2- or even 3-drug regimen, e.g. droperidol, ondansetron and dexamethasone. If the patients experience PONV despite treatment or prophylaxis, they should be treated with a drug from a group different from the one used earlier.
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The cerebral circulation is innervated by sympathetic, parasympathetic and sensory nerves which store a number of neurotransmitters. The significance of these for primary headache has been evaluated. ⋯ Upon treatment with sumatriptan, head pain subsided and neuropeptide release normalized. These data show the involvement of sensory and parasympathetic mechanisms in the pathophysiology of primary headache.
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Review Case Reports
[GHB--dangerous, addictive and uncontrollable "party drug"].
This report reviews the pharmacology, toxicity and abuse pattern of gamma-hydroxybutyrate (GHB). The legislative changes pertaining to this substance are also addressed. ⋯ It is concluded that GHB is widely abused, particularly among the younger generation, and that further cases of severe intoxication are likely to occur as long as the substance is easily available from countless sources, including via the Internet. Despite the classification of GHB as a narcotic in Sweden and several other countries, continued problems are expected since the precursors gamma-butyrolactone (GBL) and 1,4-butanediol (BD) are widely--and legally--available.