Pneumonologia i alergologia polska
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Pneumonol Alergol Pol · Jan 2008
Case Reports[Wegener's granulomatosis presenting with ischaemic stroke].
Wegener's granulomatosis (WG) is a systemic disease of unknown origin characterized by necrotizing granulomatous vasculitis that involves primarily the upper and the lower respiratory tracts and the kidneys. A 44-year-old woman presenting with unusual neurological manifestation is reported. ⋯ A diagnosis of WG was confirmed by histological examination of specimen obtained during open lung biopsy. During the combination chemotherapy with prednisolone and cyclophosphamide, neurological symptoms decreased and clinical condition significantly improved.
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This article presents a review of ultrasonographic methods and their usefulness in pulmonary diagnostics. Because of its advantages ultrasonography offers a quick, cheap, and safe diagnostics of variety of pulmonary diseases. ⋯ Some restrictions of this tool were mentioned. The newest methods of endobronchial ultrasound were also discussed.
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Pneumonol Alergol Pol · Jan 2008
Case Reports[Long-term remission after erlotinib therapy in an elderly patient with advanced non-small-cell lung cancer. Case report and conclusions for clinical practice].
Small molecule tyrosine kinase inhibitors (TKIs) of epidermal growth factor receptor (EGFR) - gefitinib and erlotinib - have recently been used as a therapeutic option in advanced non-small cell lung cancer (NSCLC) patients relapsing after first- or second-line chemotherapy. We report here a case of long-term remission in an elderly, non-smoking woman with advanced NSCLC after chemotherapy failure, who was selected for erlotinib therapy using demographic and clinical criteria. Based on this example and on the literature data we discuss the need for careful patient selection for this new therapeutic method.
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Pneumonol Alergol Pol · Jan 2008
Controlled Clinical Trial[Pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis with inspiratory muscle training].
Evaluation of effectiveness of pulmonary rehabilitation in patients with idiopathic pulmonary fibrosis (IPF) has not yet been presented in medical literature. The objective of the study is to analyze the influence of inspiratory muscle training on dyspnea (oxygen cost diagram [OCD], baseline dyspnea index [BDI]), quality of life (SF-36), results of 6 MWT (distance, dyspnea in Borg's scale), maximal inspiratory pressure (MIP), and lung function tests (IC, TLC, VC, FEV1, DLCO(SB), DLCO/VA) in patients with IPF. ⋯ Adding inspiratory muscle training increases effectiveness of pulmonary rehabilitation in IPF patients.
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Obstructive sleep apnea (OSA) is a well-recognized risk factor of cardiovascular disorders and is related to metabolic syndrome. The aim of this study was to evaluate the effect of BMI and AHI/RDI on metabolic disturbances in patients suspected of OSA. ⋯ Our findings support the results of previous studies showing the influence of OSA alone on metabolic disturbances. However, BMI has major impact on metabolic variables.