Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Feb 2023
Associations of ANGPTL6, DOCK6, FABP1, and PCSK9 single nucleotide variants and hypercholesterolemia in the Polish population: a cross-sectional study.
Hypercholesterolemia is a chronic noncommunicable disease predisposing to cardiovascular diseases. Genome‑wide association studies have shown that more than 500 common nucleotide variants are associated with dyslipidemia. ⋯ FABP1 rs2919872 and ANGPTL6 rs8112063 are associated with a risk of hypercholesterolemia in the Polish population.
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Pol. Arch. Med. Wewn. · Feb 2023
Thin-cap fibroatheroma and increased coronary intima-media thickness are associated with an altered arginine metabolites balance.
Arginase inhibition increases plasma citrulline and citrulline / ornithine (C/O) ratio, and reduces plasma ornithine and ornithine / arginine (O/A) ratio in an animal model of myocardial infarction (MI). ⋯ Enhanced arginase activity over nitric oxide synthase following ischemia was associated with the presence of TCFA in the culprit lesion, while a similar metabolic shift in the chronic phase correlated with a greater thickness of the intima‑media in the adjacent non‑culprit IRA segments.