British medical journal
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British medical journal · Sep 1971
Biography Historical ArticleWilliam Murrell, physician and practical therapist.
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British medical journal · Sep 1971
Randomized Controlled Trial Clinical TrialComparative effect of pethidine, trichloroethylene, and Entonox on fetal and neonatal acid-base and PO2.
The second stage of labour is associated with relative fetal hypoxia and progressive metabolic acidosis. Maternal analgesia can increase the danger, especially for the high-risk fetus. ⋯ Capillary samples were also taken 45 to 60 minutes after birth in 88 of the babies to estimate the rate of neonatal recovery. Entonox proved safer than trichloroethylene, and babies treated with it maintained their Po(2) before birth, had better Apgar scores at birth, and one hour later were significantly less acidotic and much better oxygenated.
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Two patients suffering from cardiovascular beriberi presented with different clinical manifestations. One had the classical features of a high cardiac output with raised jugular venous pressure and gross oedema. ⋯ Cardiovascular beriberi has a high mortality when untreated. Both patients responded dramatically to thiamine, and this emphasizes the importance of considering thiamine deficiency as a cause of heart failure even when the cardiac output is low.