British medical journal
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Of 41 cases of acute paracetamol poisoning one died of gastrointestinal haemorrhage and acute massive necrosis of the liver, three became jaundiced, and 13 others had biochemical evidence of hepatocellular damage. Liver damage is a toxic effect which is present in most patients who ingest more than 15 g. of paracetamol. ⋯ Profound hypoglycaemia and metabolic acidosis may also complicate severe poisoning. Plasma levels of para-aminophenol fall rapidly, and procedures currently used to enhance the elimination of the drug cannot be expected to prevent development of hepatic damage.
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British medical journal · Jul 1970
Routine induction of labour by amniotomy and simultaneous Syntocinon (synthetic oxytocin) infusion.
Of 2,272 deliveries between 1 October, 1967 and 31 December, 1968 290 were induced by simultaneous intravenous Syntocinon (synthetic oxytocin) at amniotomy. The hazards of induction of labour are greatly reduced when this method is used routinely. ⋯ Within 12 hours 221 patients were delivered, and this short induction-delivery interval resulted in an extremely low maternal and fetal morbidity. It is believed that with proper safeguards and in the light of present knowledge this is the method of choice.