Archives of pediatrics & adolescent medicine
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Arch Pediatr Adolesc Med · Jun 2012
Review Meta AnalysisHypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis.
To establish the evidence of therapeutic hypothermia for newborns with hypoxic ischemic encephalopathy(HIE). ⋯ Hypothermia improves survival and neurodevelopment in newborns with moderate to severe HIE.Total body cooling and selective head cooling are effective methods in treating newborns with HIE. Clinicians should consider offering therapeutic hypothermia as part of routine clinical care to these newborns.
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Arch Pediatr Adolesc Med · Jun 2012
Multicenter StudyMulticenter study of neurodevelopment in 3-year-old children with and without single-suture craniosynostosis.
To evaluate the hypothesis that 3-year-old children with single-suture craniosynostosis would receive lower neurodevelopmental scores than a comparable group of children born with patent sutures. ⋯ In this large, carefully controlled, multicenter study, we observed consistently lower mean neurodevelopmental scores in children with single-suture craniosynostosis compared with controls. These results provide further support for neurodevelopmental screening in young children with single-suture craniosynostosis.
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Published guidelines for resuscitation of extremely premature infants emphasize the importance of the gestational age of the infant. However, some ethicists and pediatricians have questioned these guidelines, suggesting that this may represent a form of discrimination. A policy of nonresuscitation of elderly patients older than a certain age would constitute a form of ageism and would likely be unacceptable to the broader community. ⋯ There are 2 levels of gestational ageism and 2 separate strands of argument against gestational age guidelines. I conclude that resuscitation decisions for premature infants share many features with those for elderly patients, although there are also some relevant differences. I propose the use of gestational age equivalence as an alternative framework for practice.
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Arch Pediatr Adolesc Med · Jun 2012
Randomized Controlled TrialStaphylococcus aureus colonization in children with community-associated Staphylococcus aureus skin infections and their household contacts.
To measure prevalence of Staphylococcus aureus colonization in household contacts of children with acute S aureus skin and soft tissue infections (SSTI), determine risk factors for S aureus colonization in household contacts, and assess anatomic sites of S aureus colonization in patients and household contacts. ⋯ Household contacts of children with S aureus SSTI had a high rate of MRSA colonization compared with the general population. The inguinal fold is a prominent site of MRSA colonization, which may be an important consideration for active surveillance programs in hospitals.
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Arch Pediatr Adolesc Med · Jun 2012
Polygenic risk, rapid childhood growth, and the development of obesity: evidence from a 4-decade longitudinal study.
To test how genomic loci identified in genome-wide association studies influence the development of obesity. ⋯ Genetic variation linked with obesity risk operates, in part, through accelerating growth in the early childhood years after birth. Etiological research and prevention strategies should target early childhood to address the obesity epidemic.